Association of LEPR Gln223Arg polymorphism with T2DM: A meta-analysis

• Several polymorphisms of LEPR gene have been found in populations exhibiting different morbidity of diabetes.
• A meta-analysis was conducted to evaluate the association of LEPR Gln223Arg polymorphism with type 2diabetes (T2DM).
• Sixteen individual studies with 7827 subjects were included into the meta-analysis, with six studies performed in Caucasian countries, the other ten studies performed in Asian.
• Current studies suggest that LEPR Gln223Arg polymorphism may not affect the susceptibility with type 2diabetes (T2DM).

A meta-analysis was conducted to evaluate the association of LEPR Gln223Arg polymorphism with type 2diabetes (T2DM). Sixteen individual studies with 7827 subjects were included into the meta-analysis. Current studies suggest that LEPR Gln223Arg polymorphism may not affect the susceptibility with type 2diabetes (T2DM).