کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2797074 1155634 2012 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effectiveness of gestational diabetes treatment: A systematic review with quality of evidence assessment
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Effectiveness of gestational diabetes treatment: A systematic review with quality of evidence assessment
چکیده انگلیسی

AimsTo evaluate the effectiveness of gestational diabetes (GDM) treatment compared to usual antenatal care, in the prevention of adverse pregnancy outcomes. Additionally, to assess the quality of the evidence to support GDM treatment according to GRADE guidelines.MethodsFourteen electronic databases and reference lists of relevant literature were searched for articles published from inception to February, 2012. Controlled clinical trials comparing GDM treatment to usual antenatal care were included. Independent extraction of articles was done by two authors using predefined data fields.ResultsSeven trials involving 3157 women were included. We found high quality evidence that treatment of GDM reduces macrosomia (RR = 0.47; 95% CI, 0.34–0.65; NNT = 11.4) and large for gestational age birth (RR = 0.57; 95% CI, 0.47–0.71; NNT = 12.2); moderate quality evidence that treatment reduces preeclampsia (RR = 0.61; 95% CI, 0.46–0.81; NNT = 21.0) and hypertensive disorders in pregnancy (RR = 0.64; 95% CI, 0.51–0.81; NNT = 18.1); and low quality evidence that treatment reduces shoulder dystocia (RR = 0.41; 95% CI, 0.22–0.76; NNT = 48.8). No statistically significant reduction was seen for caesarean section. No increase in small for gestational age or preterm birth was found.ConclusionsTreatment of GDM is effective in reducing macrosomia (high quality evidence), preeclampsia and shoulder dystocia.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diabetes Research and Clinical Practice - Volume 98, Issue 3, December 2012, Pages 396–405
نویسندگان
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