کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2797231 | 1155638 | 2011 | 10 صفحه PDF | دانلود رایگان |

AimsTo describe the distribution of HOMA-IR levels in a general nondiabetic population and its relationships with metabolic and lifestyles characteristics.MethodsCross-sectional study. Data from 2246 nondiabetic adults in a random Spanish population sample, stratified by age and gender, were analyzed. Assessments included a structured interview, physical examination, and blood sampling. Generalized additive models (GAMs) were used to assess the effect of lifestyle habits and clinical and demographic measurements on HOMA-IR. Multivariate GAMs and quantile regression analyses of HOMA-IR were carried out separately in men and women.ResultsThis study shows refined estimations of HOMA-IR levels by age, body mass index, and waist circumference in men and women. HOMA-IR levels were higher in men (2.06) than women (1.95) (P = 0.047). In women, but not men, HOMA-IR and age showed a significant nonlinear association (P = 0.006), with increased levels above fifty years of age. We estimated HOMA-IR curves percentile in men and women.ConclusionsAge- and gender-adjusted HOMA-IR levels are reported in a representative Spanish adult non-diabetic population. There are gender-specific differences, with increased levels in women over fifty years of age that may be related with changes in body fat distribution after menopause.
Journal: Diabetes Research and Clinical Practice - Volume 94, Issue 1, October 2011, Pages 146–155