کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2797820 1155667 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of thyroid hormone on serum glycated albumin levels: Study on non-diabetic subjects
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Effects of thyroid hormone on serum glycated albumin levels: Study on non-diabetic subjects
چکیده انگلیسی

Glycated albumin (GA) is used alongside glycated hemoglobin (HbA1C) as an indicator of glycemic control. Although serum GA levels are affected mainly by plasma glucose, they are also influenced by serum albumin metabolism. Thyroid hormone is known to promote albumin catabolism, and it is thus thought to affect serum GA levels. In the present study, the effects of thyroid hormone on serum GA measurements were investigated in patients with thyroid dysfunction. Six patients with untreated hypothyroidism and 17 patients with untreated thyrotoxicosis were investigated. Patients who had anemia or diabetes were excluded. A total of 25 non-diabetic, euthyroid individuals were enrolled as controls. HbA1C, serum GA, thyroid-stimulating hormone (TSH), free triiodothyronine (T3), and free thyroxine (T4) levels were measured in all these subjects, and their relationships were examined. Although no intergroup differences were observed for HbA1C, serum GA was significantly higher among patients with hypothyroidism than controls, and significantly lower among patients with thyrotoxicosis. Serum GA had a significant positive correlation with serum TSH and significant inverse correlations with free T3 and free T4.Thyroid hormone levels are inversely associated with serum GA levels. Cautions are necessary when evaluating serum GA levels in patients with thyroid dysfunction.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diabetes Research and Clinical Practice - Volume 84, Issue 2, May 2009, Pages 163–167
نویسندگان
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