کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2798119 1155679 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Vildagliptin dose-dependently improves glycemic control in Japanese patients with type 2 diabetes mellitus
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Vildagliptin dose-dependently improves glycemic control in Japanese patients with type 2 diabetes mellitus
چکیده انگلیسی

ObjectiveTo assess the efficacy and tolerability of vildagliptin (10, 25 or 50 mg bid) in Japanese patients with type 2 diabetes mellitus (T2DM).MethodsThis 12-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study was performed in 291 patients. The primary assessment was change from baseline to endpoint in HbA1c.ResultsBaseline HbA1c averaged 7.4%, and the between-treatment difference (vildagliptin–placebo) in the HbA1c adjusted mean change was −0.8%, −1.0% and −1.2% with vildagliptin 10, 25 and 50 mg bid, respectively (p < 0.001). Relative to baseline, body weight did not change significantly in vildagliptin groups. There was no increase in incidence of adverse events in the vildagliptin groups (62.0%, 62.5% and 61.8%, 10, 25 and 50 mg bid, respectively) compared to placebo (73.6%). No deaths or drug-related serious adverse events were reported. Seven hypoglycemic events were observed (four events (n = 3), two events (n = 2), and one event (n = 1) in the vildagliptin 10 and 50 mg bid, and placebo, respectively) and none of them were severe or dose related.ConclusionVildagliptin 50 mg bid was considered to be the most effective and well-tolerated dose, and therefore can be considered the recommended clinical dose for Japanese patients with T2DM.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diabetes Research and Clinical Practice - Volume 83, Issue 2, February 2009, Pages 233–240
نویسندگان
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