کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2798359 | 1155687 | 2008 | 6 صفحه PDF | دانلود رایگان |
ObjectiveTo assess the optimal dose and timing of subcutaneous injection of insulin Aspart (IAsp) in relation to meal to mimic first phase insulin response in patients with recently diagnosed type 2 diabetes.Design and methodsTwenty patients were randomised in a double blind, double dummy design to four standard meal tests with pre-meal injection of insulin Aspart 0.08 IU/kg BW 30 min before the meal, insulin Aspart 0.04 IU/kg BW 30 or 15 min before the meal and placebo.ResultsAll three insulin regimes significantly reduced postprandial glucose increment (area under the curve AUC−30 to 240 min) and peak plasma glucose increment (ΔCmax) compared with placebo. Postprandial glucose increment AUC−30 to 240 min but not ΔCmax was significantly lower with IAsp 0.08 IU/kg BW as compared to IAsp 0.04 IU/kg BW, (p < 0.03 and p = 0.18). One patient experienced hypoglycaemia after injection of IAsp 0.08 IU/kg BW. No difference in postprandial glucose profile was demonstrated whether IAsp 0.04 IU/kg BW was administrated 15 or 30 min before mealtime.ConclusionsIAsp 0.04 IU/kg BW injected subcutaneously 15 or 30 min before meal reduced the postprandial blood glucose increment without risk of hypoglycaemia in patients with recently diagnosed type 2 diabetes. Doubling of the IAsp dose significantly reduced the postprandial glucose increment but increased the risk of hypoglycaemia.
Journal: Diabetes Research and Clinical Practice - Volume 80, Issue 2, May 2008, Pages 293–298