Advanced diagnostic methods of small fiber diabetic peripheral neuropathy

Early detection and diagnosis is most important in small fiber diabetic peripheral neuropathy (DPN) management. Traditionally used diagnostic methods could not detect different nerve fiber function and had low sensitivity and specificity and huge inter- and intra-individual variation and coefficient of variance. So we need more objective and sensitive and specific diagnostic tools. In this review, we will discuss about recently developed diagnostic methods of small fiber DPN.