کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2799310 | 1155967 | 2014 | 8 صفحه PDF | دانلود رایگان |
• Placental function is critical to a successful outcome at every stage of pregnancy from implantation to delivery.
• The primate placenta has several unique features, including secreting corticotropin-releasing hormone.
• Specific placental receptors also enable substantial amounts of maternal antibody and iron to be transferred to the fetus.
The placenta is essential to mammalian pregnancy with many roles beyond just nutrient supply, including both endocrine and immune functions. During the course of evolution, the placenta of higher primates has acquired some unique features, including the capacity to secrete corticotropin-releasing hormone (CRH). In addition, a placental receptor for IgG enables particularly high levels of protective maternal antibody to reach the fetus before birth. This paper reviews the placental biology of primates, and discusses its involvement in adrenocortical hormone activity during pregnancy, the transfer of maternal antibody, and finally the delivery of maternal iron to the fetus, which is needed for normal brain development. An understanding of these vital functions during a full-term, healthy pregnancy provides insights into the consequences of gestational disturbances, such as maternal stress, illness, and undernutrition, which have even larger ramifications if the infant is born premature.
Journal: Frontiers in Neuroendocrinology - Volume 35, Issue 4, October 2014, Pages 439–446