کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2799426 1155981 2010 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Glutamatergic synaptic transmission in neuroendocrine cells: Basic principles and mechanisms of plasticity
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Glutamatergic synaptic transmission in neuroendocrine cells: Basic principles and mechanisms of plasticity
چکیده انگلیسی

Glutamate synapses drive the output of neuroendocrine cells in the hypothalamus, but until recently, relatively little was known about the fundamental properties of transmission at these synapses. Here we review recent advances in the understanding of glutamate signals in magnocellular neurosecretory cells (MNCs) in the paraventricular (PVN) and supraoptic nuclei (SON) of the hypothalamus that serve as the last step in synaptic integration before neurohormone release. While these synapses exhibit many similarities with other glutamate synapses described throughout the brain, they also exhibit a number of unique properties that are particularly well suited to the physiology of this system and will be discussed here. In addition, a number of recent studies begin to provide insights into new forms of synaptic plasticity that may be common in other brain regions, but in these cells, may serve important adaptive roles.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Frontiers in Neuroendocrinology - Volume 31, Issue 3, July 2010, Pages 296–306
نویسندگان
, , ,