کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2799500 | 1155988 | 2009 | 15 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Who’s in charge? Nuclear receptor coactivator and corepressor function in brain and behavior Who’s in charge? Nuclear receptor coactivator and corepressor function in brain and behavior](/preview/png/2799500.png)
Steroid hormones act in brain and throughout the body to regulate a variety of functions, including development, reproduction, stress and behavior. Many of these effects of steroid hormones are mediated by their respective receptors, which are members of the steroid/nuclear receptor superfamily of transcriptional activators. A variety of studies in cell lines reveal that nuclear receptor coregulators are critical in modulating steroid receptor-dependent transcription. Thus, in addition to the availability of the hormone and the expression of its receptor, nuclear receptor coregulators are essential for efficient steroid-dependent transactivation of genes. This review will highlight the importance of nuclear receptor coregulators in modulating steroid-dependent gene expression in brain and the regulation of behavior.
Journal: Frontiers in Neuroendocrinology - Volume 30, Issue 3, August 2009, Pages 328–342