Effects of lipids and lipoproteins on diabetic foot in people with type 2 diabetes mellitus: A meta-analysis

BackgroundTo conduct a meta-analysis of case–control studies to determine the effects of lipids and lipoproteins on morbidity of diabetic foot in adults with type 2 diabetes.MethodsWe searched the PubMed and EMBASE to identify eligible studies. The Newcastle–Ottawa Quality Assessment Scale was used to determine the quality of selected studies. We assessed the strength of associations using standardized mean differences with 95% confidence intervals.ResultsA total of 4 articles were found. Decreased HDL-cholesterol had a significant association with diabetic foot susceptibility in fixed-effects model, but no significant associations were found between diabetic foot and LDL-cholesterol, TC or TG levels.ConclusionsOur results suggested that decreased HDL-cholesterol was associated with diabetic foot, so possible measures to prevent diabetic foot should include targeting increases in HDL-cholesterol.