کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2805437 1157054 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nonalcoholic fatty liver disease and statins
ترجمه فارسی عنوان
بیماری کبدی چرب غیرطبیعی و استاتین ها
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
چکیده انگلیسی

ObjectiveNonalcoholic fatty liver disease (NAFLD) is the most frequent cause of elevated transaminase levels and affects approximately one third of the general population. Patients with NAFLD are at increased risk for cardiovascular events, which represent the leading cause of death in this population. We discuss the safety and efficacy of statins in this population.Materials/methodsWe reviewed the most recent literature on the safety of statins in patients with NAFLD and on their effects on liver histology and cardiovascular events.ResultsIt appears that statins can be safely administered to patients with NAFLD, including those with elevated transaminase levels (< 3 times the upper limit of normal). Post-hoc analyses of randomized controlled trials also suggest that statins might reduce cardiovascular morbidity in this population. On the other hand, there are few and controversial data on the effects of statins on liver histology in patients with NAFLD.ConclusionsStatins appear to be safe and might also reduce cardiovascular events in patients with NAFLD. Ongoing and future studies will clarify whether statins might also have a role in the treatment of NAFLD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Metabolism - Volume 64, Issue 10, October 2015, Pages 1215–1223
نویسندگان
, , , ,