کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2805558 | 1157064 | 2014 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Chemerin levels as predictor of acute coronary events: A case–control study nested within the veterans affairs normative aging study Chemerin levels as predictor of acute coronary events: A case–control study nested within the veterans affairs normative aging study](/preview/png/2805558.png)
ObjectiveChemerin is a recently identified adipocytokine that has been positively correlated with the presence and severity of coronary artery disease (CAD). However, no studies have examined circulating chemerin levels as a predictor of acute coronary syndrome (ACS). The purpose of this study is to evaluate whether chemerin levels predict the onset of ACS.Materials/MethodsWe studied 90 men whose serum had been collected at least 2 years before the development of ACS, and 162 controls matched with the cases in a 1:2 fashion for age and year of collection. The mean age of the cohort was 66.3 ± 9.6 years (range 34–84 years). Serum chemerin levels were measured with a commercially available enzyme-linked immunosorbent assay.ResultsAge was positively associated with chemerin levels (r = 0.39, p < 0.001). Logistic regression analysis, adjusting for years since blood collection, demonstrated a null association between chemerin levels and the odds ratio for development of ACS (OR: 0.99, 95% CI [0.99–1.001]). This association remained null after adjusting for age (OR: 0.99 95% CI [0.99–1.001]).ConclusionsAlthough cross-sectional and case–control studies suggest a positive association between chemerin levels and CAD, we demonstrate that chemerin levels do not predict the development of ACS.
Journal: Metabolism - Volume 63, Issue 6, June 2014, Pages 760–766