کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2810264 | 1158422 | 2014 | 7 صفحه PDF | دانلود رایگان |
• Lipoproteins in the brain are mostly made in the brain.
• Lipoprotein composition in the brain is different from that in the circulation.
• Neurons and astrocytes coordinate lipoprotein metabolism in the brain.
• Lipoproteins help to regulate neurobehavioral function and energy balance.
Lipoproteins in plasma transport lipids between tissues, however, only high-density lipoproteins (HDL) appear to traverse the blood–brain barrier (BBB); thus, lipoproteins found in the brain must be produced within the central nervous system. Apolipoproteins E (ApoE) and ApoJ are the most abundant apolipoproteins in the brain, are mostly synthesized by astrocytes, and are found on HDL. In the hippocampus and other brain regions, lipoproteins help to regulate neurobehavioral functions by processes that are lipoprotein receptor-mediated. Moreover, lipoproteins and their receptors also have roles in the regulation of body weight and energy balance, acting through lipoprotein lipase (LPL) and the low-density lipoprotein (LDL) receptor-related protein (LRP). Thus, understanding lipoproteins and their metabolism in the brain provides a new opportunity with potential therapeutic relevance.
Journal: - Volume 25, Issue 1, January 2014, Pages 8–14