Glutathione-S-transferase M1 and T1 genes and gastric cancer: A case control study in North Indian population

BackgroundDifference in the capacity of xenobiotic metabolising enzymes might be an important factor in genetic susceptibility to cancer.MethodsA case control study involving forty one gastric cancer patients and one hundred and thirty controls was carried out to determine the frequency of GSTM1 and GSTT1 null genotypes. The frequency of GSTM1 and GSTT1 null genotype was observed by carrying out multiplex PCR.ResultsThere was no difference in the frequencies of the GSTM1 and GSTT1 null and the combined GSTM1 and GSTT1 null genotype between patients and control.ConclusionsOur data suggest that GSTM1 and GSTT1 status may not influence the risk of developing gastric cancer.