کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2892710 1172369 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The positive relationship of serum paraoxonase-1 activity with apolipoprotein E is abrogated in metabolic syndrome
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
The positive relationship of serum paraoxonase-1 activity with apolipoprotein E is abrogated in metabolic syndrome
چکیده انگلیسی


• HDL contains paraoxonase-1 (PON-1) which has strong anti-oxidative properties.
• ApoE may enhance paraoxonase-1 activity in vitro.
• PON-1 was related to apoE in subjects without metabolic syndrome (r = 0.376, p < 0.001).
• This relation was absent in subjects with metabolic syndrome.
• Higher apoE levels may confer higher PON-1 activity.

BackgroundHigh density lipoproteins (HDL) contain paraoxonase-1 (PON-1), which has strong anti-oxidative properties. Apolipoprotein E (apoE) may enhance PON-1 activity in vitro, but the extent to which PON-1 activity is determined by circulating apoE levels is unknown. Here we determined relationships of serum PON-1 activity with apoE in subjects without and with metabolic syndrome (MetS).MethodsWe measured PON-1 activity (arylesterase activity), plasma apoE and serum amyloid A (SAA) in 93 subjects without and in 75 subjects with MetS (25 and 54 subjects with Type 2 diabetes mellitus (T2DM), respectively; p < 0.001).ResultsPON-1 activity was lower in MetS (p < 0.005) coinciding lower HDL cholesterol, apoA-I (p < 0.001)) and SAA levels (p < 0.01), whereas apoE was increased in relation to higher triglycerides (p < 0.01). In subjects without MetS, PON-1 activity was correlated positively with apoE (r = 0.376, p < 0.001), but this relationship was absent in MetS subjects (r = 0.085, p = 0.47). Multiple linear regression analysis showed that the relationship of PON-1 activity with apoE was different in subjects with MetS compared to subjects without MetS (β = −0.270, p = 0.014 for the interaction between apoE and MetS), independently from age, sex, T2DM, use of glucose lowering drugs, anti-hypertensives and the inverse relation with SAA levels (p = 0.008). Of the individual MetS components, apoE only interacted with low HDL-C on PON-1 activity (β = −0.175, p = 0.074). The relationship of apoE with PON-1 activity was neither modified by T2DM (p = 0.49), nor by SAA (p = 0.79).ConclusionHigher apoE levels may confer higher PON-1 activity. The relationship of PON-I activity with total plasma apoE is apparently abrogated in MetS.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Atherosclerosis - Volume 230, Issue 1, September 2013, Pages 6–11
نویسندگان
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