کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2892778 1172386 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
miR-146a is modulated in human endothelial cell with aging
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
miR-146a is modulated in human endothelial cell with aging
چکیده انگلیسی

BackgroundIncreasing evidence has demonstrated that the senescence of vascular endothelial cells has critical roles in the pathogenesis of vascular dysfunction such as atherosclerosis and thrombosis. MicroRNA (miR) are small non-coding RNAs that inhibit gene expression by binding to complementary sequences in the 3′UTR of their target mRNAs. MiRs modulate a variety of biological functions such as cell development, cell differentiation, and apoptosis. Moreover, several miRs involved in endothelial cell function have been identified.Methods and resultsThrough a microarray approach, we have identified a miR-146a that is progressively modulated in endothelial cells with aging. In young human umbilical vein endothelial cells, this miR is involved in a premature senescence-like phenotype through direct targeting of the NOX4 protein, implicated in cell senescence and aging.Conclusions and general significanceFinding important factors that regulate endothelial cell senescence, like miR-146a, will help provide novel therapeutic strategies for vascular disorders.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Atherosclerosis - Volume 217, Issue 2, August 2011, Pages 326–330
نویسندگان
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