کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2892845 1172391 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Carotid distension and distensibility impairment in individuals affected by familial combined hyperlipidemia
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Carotid distension and distensibility impairment in individuals affected by familial combined hyperlipidemia
چکیده انگلیسی

ObjectiveTo investigate whether individuals affected by familial combined hyperlipidemia, a common lipid disorder increasing the cardiovascular risk, had different carotid ultrasound parameters compared to control subjects without this family disorders.Methods127 cases and 127 controls matched for age and gender were enrolled. Serum glucose, total cholesterol, high-density lipoprotein-cholesterol, triglycerides, ApoB, insulinemia were measured by standard laboratory techniques. All the subjects underwent B-mode ultrasonography to measure the end-diastolic and end-systolic diameter of the common carotid artery and, successively, to calculate distensibility, compliance, Young's elastic modulus and distension.ResultsCarotid diameter and Young's elastic modulus were significantly greater among FCH subjects than among controls, and carotid distensibility, compliance, distension and score distension were significantly lower than control, also after analysis of covariance in order to adjust all the carotid indexes for confounding variables. A multiple regression analysis confirmed that familial combined hyperlipidemia status was correlated to carotid indexes. In a model including the lipid parameters, triglycerides was the only lipid variable correlated with distensibility but not with distension.ConclusionThis hyperlipidemia, particularly hypertrigliceridemia, could be the direct responsibility of carotid modification leading to the impairment of the distension/distensibility that, in turn, makes the patients prone to atherosclerosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Atherosclerosis - Volume 212, Issue 1, September 2010, Pages 177–180
نویسندگان
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