کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2893093 1172404 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Bone morphogenetic protein-2 may represent the molecular link between oxidative stress and vascular stiffness in chronic kidney disease
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Bone morphogenetic protein-2 may represent the molecular link between oxidative stress and vascular stiffness in chronic kidney disease
چکیده انگلیسی

Oxidative stress and vascular calcifications are emergent risk factors for the accelerated atherosclerosis process featuring chronic kidney disease (CKD). Vascular calcification is an active process similar to bone modelling, where BMP-2 may play a pathogenic role. Aim of our study was to investigate the link between oxidative stress, BMP-2 protein expression and vascular disease in CKD.We enrolled 85 CKD patients (K-DOQI stage II or higher) and 41 healthy individuals. 8-Oxo-7,8-dihydro-2′-deoxyguanosine (8-OHdG) was used as a marker of oxidative stress. Brachial-ankle pulse wave velocity (baPWV) was used as a measure of arterial stiffness.BMP-2 serum levels were significantly higher in CKD patients than in controls (p < 0.0001). Serum 8-OHdG levels were significantly higher in CKD patients compared to controls (p < 0.05). BMP-2 serum levels were inversely associated with eGFR (r = −0.3; p = 0.01) and directly correlated with 8-OHdG serum concentrations (r = −0.3; p = 0.03). Arterial stiffness was inversely correlated with eGFR (r = −0.4; p = 0.001) and directly correlated with BMP-2 (r = 0.3; p = 0.03), 8-OHdG (r = 0.4, p = 0.02) and phosphorus serum levels (r = 0.3; p = 0.007). In a multiple regression model, phosphorus and BMP-2 were independently correlated with baPWV. In vitro exposure to H2O2 induced a time and dose-dependent increase in BMP-2 expression in an immortalized endothelial cell line. Moreover, H2O2 pre-incubation of cultured vascular smooth muscle cell enhanced the BMP-2-induced up-regulation of ALPL, an osteoblastic phenotype marker.Our data suggest that in CKD BMP-2 may represent the molecular link between oxidative stress and arterial stiffness due to vascular calcification.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Atherosclerosis - Volume 211, Issue 2, August 2010, Pages 418–423
نویسندگان
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