Prostanoid and isoprostanoid pathways in atherogenesis

In recent years, a lot of research effort has been focused on these lipid mediators because of their active roles in cardiovascular physiology, and because their biosynthesis is severely altered in patients with atherosclerosis. This review article describes the biological roles that prostanoids, isoprostanoids and their receptors play in atherogenesis by integrating our current knowledge of basic cellular mechanisms with the results of experimental genetic and pharmacologic studies using modulators of these pathways.