کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2893360 1172412 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Atherosclerotic mice exhibit systemic inflammation in periadventitial and visceral adipose tissue, liver, and pancreatic islets
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Atherosclerotic mice exhibit systemic inflammation in periadventitial and visceral adipose tissue, liver, and pancreatic islets
چکیده انگلیسی

ObjectiveAtherosclerosis is a chronic inflammatory disease of major conduit arteries. Similarly, obesity and type 2 diabetes mellitus are associated with accumulation of macrophages in visceral white adipose tissue and pancreatic islets. Our goal was to characterize systemic inflammation in atherosclerosis with hypercholesterolemia, but without obesity.Methods and resultsWe compared 22-week-old apolipoprotein E knockout (ApoE−/−) with wild-type mice kept for 14 weeks on a high cholesterol (1.25%) diet (CD, n = 8) and 8-week-old ApoE−/− with wild-type mice kept on a normal diet (ND, n = 8). Hypercholesterolemic, atherosclerotic ApoE−/− mice on CD exhibited increased macrophages and T-cells in plaques and periadventitial adipose tissue that revealed elevated expression of MIP-1α, IL-1β, IL-1 receptor, and IL-6. Mesenteric adipose tissue and pancreatic islets in ApoE−/− mice showed increased macrophages. Expression of IL-1β was enhanced in mesenteric adipose tissue of ApoE−/− mice on CD. Furthermore, these mice exhibited steatohepatitis with macrophage and T-cell infiltrations as well as increased MIP-1α and IL-1 receptor expression. Blood glucose, insulin and total body weight did not differ between the groups.ConclusionsIn hypercholesterolemic lean ApoE−/− mice, inflammation extends beyond atherosclerotic plaques to the periadventitial and visceral adipose tissue, liver, and pancreatic islets without affecting glucose homeostasis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Atherosclerosis - Volume 207, Issue 2, December 2009, Pages 360–367
نویسندگان
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