کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2893454 1172414 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Associations of very high C-reactive protein concentration with psychosocial and cardiovascular risk factors in an ageing population
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Associations of very high C-reactive protein concentration with psychosocial and cardiovascular risk factors in an ageing population
چکیده انگلیسی

BackgroundRaised levels of C-reactive protein (CRP), a marker of low grade systemic inflammation, is common in ageing populations although the relevance of very highly elevated CRP (>10 mg/L) remains unclear. We examined cross-sectional associations of very high CRP with psychosocial, behavioural, and cardiovascular risk factors.MethodsParticipants were 5307 men and women from the English Longitudinal Study of Ageing, a study of community dwelling older adults (46.0% men, aged 66.5 ± 10.1 years). Psychosocial (social status, marital status, depressive symptoms), behavioural (smoking, physical activity, alcohol), and cardiovascular risk factors (blood pressure, cholesterol, glycated haemoglobin, body mass index, waist) were assessed in relation to CRP.ResultsA very high CRP concentration was recorded in 7.5% of the sample. After adjustments for age, sex, acute infection and chronic inflammatory conditions, very high CRP was associated with lower social position, depressive symptoms, physical inactivity, smoking, and alcohol abstinence. There was a linear trend for increased prevalence of cardiovascular risk factors across CRP categories representing low (<1 mg/L), medium (1 to <3 mg/L), high (3–10 mg/L), and very high (>10 mg/L), although little differences in risk between high and very high groups were observed.ConclusionsVery high levels of CRP in elderly participants might reflect chronic health and psychosocial adversity, independently of acute infection.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Atherosclerosis - Volume 206, Issue 2, October 2009, Pages 599–603
نویسندگان
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