کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2893585 1172416 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Leukocyte telomere length is associated with HDL cholesterol levels: The Bogalusa heart study
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Leukocyte telomere length is associated with HDL cholesterol levels: The Bogalusa heart study
چکیده انگلیسی

ObjectiveThis study examined the relationships of high-density lipoprotein cholesterol (HDL-C) with LTL and the rate of its shortening.BackgroundDiminished levels of HDL-C are associated with an increased risk for atherosclerosis. Shortened leukocyte telomere length (LTL) also entails an increased atherosclerotic risk.MethodsWe studied 472 Whites and 190 African Americans (AfAs) enrolled in the Bogalusa Heart Study. Subjects were examined serially 3–13 times for HDL-C over an average period of 27.8 years from childhood through young adulthood. LTL was measured twice during adulthood at a mean age of 31.5 years (baseline exam) and 37.8 years (follow-up exam). HDL-C trajectories with age were constructed and the area under the curve (AUC) was used as a measure of cumulative HDL-C levels.ResultsMultivariate regression analyses showed that LTL was positively associated with HDL-C in childhood (regression coefficient (bp per mg/dL) β = 3.1, p = 0.024), adulthood (β = 4.4, p = 0.058) and AUC from childhood to adulthood (β = 12.2, p = 0.0004) in the combined sample of AfAs and Whites. The association between LTL and HDL-C AUC was stronger in females (β = 18.5, p < 0.001) than in males (β = 2.9, p = 0.590) (difference in slopes p = 0.037). A slower rate of LTL shortening per year was associated with higher HDL-C AUC in the total sample (p = 0.033), adjusting for baseline LTL.ConclusionsAs HDL-C exerts anti-oxidant and anti-inflammatory effects and LTL registers the accruing burden of oxidative stress and inflammation, the association between HDL-C and LTL might be explained by the lifelong status of oxidative stress and inflammation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Atherosclerosis - Volume 205, Issue 2, August 2009, Pages 620–625
نویسندگان
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