کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2895282 1172456 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of hypercholesterolemia on transendothelial EBD–albumin permeability and lipid accumulation in porcine iliac arteries
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Effect of hypercholesterolemia on transendothelial EBD–albumin permeability and lipid accumulation in porcine iliac arteries
چکیده انگلیسی

Hypercholesterolemia is associated with increased cardiovascular mortality and is known to promote the advancement of atherosclerotic lesions in experimental animal models. Juvenile swine were fed a normal or high-cholesterol diet, and the transendothelial macromolecular permeability of the external iliac arteries of these animals was assessed by measuring the uptake rate of circulating Evans blue dye (EBD). The extent and patterns of lipid-containing lesions were also determined using en face staining with Oil Red O (ORO). Sites of ORO staining often excluded EBD, possibly via the fragmentation of the internal elastic lamina, to which EBD binds. By spatially averaging the EBD uptake in arterial segments relatively free of ORO-positive lesions, it was found that endothelial permeability to albumin was greater in hypercholesterolemic pigs than in those on a normal diet (p = 0.056).

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Atherosclerosis - Volume 184, Issue 2, February 2006, Pages 255–263
نویسندگان
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