کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2898969 1173106 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The aortic valve microenvironment and its role in calcific aortic valve disease
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
The aortic valve microenvironment and its role in calcific aortic valve disease
چکیده انگلیسی

In calcific aortic valve disease, fibrotic and calcific lesions form focally in the fibrosa layer of the valve leaflets. Layer-specific pathosusceptibility suggests that the fibrosa microenvironment is permissive to pathological development. The cellular microenvironment in the aortic valve is defined by a variety of biomechanical-, biochemical-, and extracellular-mediated factors, some of which are unique to the fibrosa. Growing evidence supports the role of these microenvironmental cues in the local regulation of side-specific valve cell phenotypes and focal pathological alterations, revealing new insights into the cellular and molecular processes that contribute to calcific aortic valve disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cardiovascular Pathology - Volume 20, Issue 3, May–June 2011, Pages 177–182
نویسندگان
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