کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2899354 1173133 2009 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Local mechanical and structural properties of healthy and diseased human ascending aorta tissue
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Local mechanical and structural properties of healthy and diseased human ascending aorta tissue
چکیده انگلیسی

ObjectiveThis study investigates the mechanics and histology of healthy and dilated human ascending aortas (AA). The regional variation in mechanical response and tissue structure were compared.MethodsRings of human AA from healthy (n=5), dilated tricuspid aortic valve (TAV, n=5), and dilated bicuspid aortic valve (BAV, n=6) patients were mechanically tested. Each aortic ring was sectioned into quadrants—anterior, posterior, medial (inner curvature) and lateral (outer curvature). Low- and high-stress elastic moduli were calculated from the equibiaxial stress strain curve to determine the local mechanical properties. Histological analysis was used to quantify the percent composition of elastin, collagen, and smooth muscle cells.ResultsBAV tissue was thinnest and contained the largest percent composition of collagen. Both TAV and BAV tissue had significantly less elastin than healthy tissue. At low strain in the circumferential direction, TAV tissue was on average the least stiff. The elastic modulus was dependent on quadrant and tissue type but not direction (isotropic). Generally, the lateral quadrant tissue was the stiffest and the medial quadrant the least stiff. There were no apparent local variations in the tissue histology.ConclusionsLocal variations in tissue thickness and mechanical properties were evident in all samples analyzed and may be linked to the type of aortic valve present.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cardiovascular Pathology - Volume 18, Issue 2, March–April 2009, Pages 83–91
نویسندگان
, , , , , , , ,