کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2916809 | 1175646 | 2016 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Post-translational Modifications in Heart Failure: Small Changes, Big Impact Post-translational Modifications in Heart Failure: Small Changes, Big Impact](/preview/png/2916809.png)
Heart failure is a complex disease process with various aetiologies and is a significant cause of morbidity and death world-wide. Post-translational modifications (PTMs) alter protein structure and provide functional diversity in terms of physiological functions of the heart. In addition, alterations in protein PTMs have been implicated in human disease pathogenesis. Small ubiquitin-like modifier mediated modification (SUMOylation) pathway was found to play essential roles in cardiac development and function. Abnormal SUMOylation has emerged as a new feature of heart failure pathology. In this review, we will highlight the importance of SUMOylation as a regulatory mechanism of SERCA2a function, and its therapeutic potential for the treatment of heart failure.
Journal: Heart, Lung and Circulation - Volume 25, Issue 4, April 2016, Pages 319–324