کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2924904 | 1175921 | 2007 | 12 صفحه PDF | دانلود رایگان |
BackgroundInfarct border zone (IBZ) geometry likely affects inducibility and characteristics of postinfarction reentrant ventricular tachycardia, but the connection has not been established.ObjectiveThe purpose of this study was to determine characteristics of postinfarction ventricular tachycardia in the IBZ.MethodsA geometric model describing the relationship between IBZ geometry and wavefront propagation in reentrant circuits was developed. Based on the formulation, slow conduction and block were expected to coincide with areas where IBZ thickness (T) is minimal and the local spatial gradient in thickness (ΔT) is maximal, so that the degree of wavefront curvature ρ ∝ ΔT/T is maximal. Regions of fastest conduction velocity were predicted to coincide with areas of minimum ΔT. In seven arrhythmogenic postinfarction canine heart experiments, tachycardia was induced by programmed stimulation, and activation maps were constructed from multichannel recordings. IBZ thickness was measured in excised hearts from histologic analysis or magnetic resonance imaging. Reentrant circuit properties were predicted from IBZ geometry and compared with ventricular activation maps after tachycardia induction.ResultsMean IBZ thickness was 231 ± 140 μm at the reentry isthmus and 1440 ± 770 μm in the outer pathway (P <0.001). Mean curvature ρ was 1.63 ± 0.45 mm−1 at functional block line locations, 0.71 ± 0.18 mm−1 at isthmus entrance-exit points, and 0.33 ± 0.13 mm−1 in the outer reentrant circuit pathway. The mean conduction velocity about the circuit during reentrant tachycardia was 0.32 ± 0.04 mm/ms at entrance-exit points, 0.42 ± 0.13 mm/ms for the entire outer pathway, and 0.64 ± 0.16 mm/ms at outer pathway regions with minimum ΔT. Model sensitivity and specificity to detect isthmus location was 75.0% and 97.2%.ConclusionsReentrant circuit features as determined by activation mapping can be predicted on the basis of IBZ geometrical relationships.
Journal: Heart Rhythm - Volume 4, Issue 8, August 2007, Pages 1034–1045