کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2957952 | 1178204 | 2013 | 7 صفحه PDF | دانلود رایگان |
BackgroundThe aim of this study was to investigate the use of imaging techniques to predict the response to cardiac resynchronization therapy (CRT) in patients with non-ischemic cardiomyopathy (NICM) by simultaneous assessment of left ventricular (LV) dyssynchrony and myocardial perfusion in a single nuclear scan of the heart.MethodsPatients indicated for CRT device implantation underwent a resting myocardial perfusion assessment with single photon emission computed tomography (MP-SPECT) examination using technetium-99 m methoxyisobutylisonitrile prior to device implantation. CardioGRAF and cardioBull software (FUJIFILM RI Pharma, Tokyo, Japan) were used to analyze the LV mechanical dyssynchrony and myocardial viability, respectively. Patient follow-ups were performed at 6 months after device implantation. CRT response was defined as a ≥10% decrease in the LV end systolic volume.ResultsA total of 43 patients with NICM were analyzed. Using the cutoff points of 6.2 for the dyssynchrony index and 66% for LV myocardial perfusion, the combined indices predicted CRT response with a sensitivity of 77.8% and specificity of 91.2%.ConclusionCombined assessment of MP-SPECT and a measure of LV mechanical dyssynchrony showed good predictive ability in patients with non-ischemic heart failure.
Journal: Journal of Arrhythmia - Volume 29, Issue 3, June 2013, Pages 180–186