کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2958951 1178304 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Altered Levels of Fatty Acids and Inflammatory and Metabolic Mediators in Epicardial Adipose Tissue in Patients With Systolic Heart Failure
ترجمه فارسی عنوان
سطح تغییرات اسید چرب و متابولیسم التهابی و متابولیک در بافت های اپوکارد در بیماران مبتلا به نارسایی قلبی سیستولیک
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی


• We examined mediators in adipose tissue depots in systolic heart failure.
• Increased IL-6 was observed in epicardial adipose tissue, suggesting inflammation.
• Examination of metabolic mediators suggests increased FA transportation.
• Monounsaturated FAs were more abundant in heart failure.
• Palmitoleic acid was correlated with parameters of progressing heart failure.

BackgroundAdipose tissue has endocrine properties, secreting a wide range of mediators into the circulation, including factors involved in cardiovascular disease. However, little is known about the potential role of adipose tissue in heart failure (HF), and the aim of this study was to investigate epicardial (EAT) and subcutaneous (SAT) adipose tissue in HF patients.Methods and ResultsThirty patients with systolic HF and 30 patients with normal systolic function undergoing thoracic surgery were included in the study. Plasma was sampled and examined with the use of enzyme-linked immunosorbent assays, whereas SAT and EAT biopsies were collected and examined by means of reverse-transcription polymerase chain reaction and gas chromatography. Significantly higher expressions of mRNA encoding interleukin-6, adrenomedullin, peroxisome proliferator–activated receptor α, and fatty acid (FA)–binding protein 3, as well as higher levels of monounsaturated FA and palmitoleic acid, were seen in the EAT of HF patients, whereas the levels of docosahexaenoic acid were lower. Palmitoleic acid levels in EAT were correlated with 2 parameters of cardiac remodeling: increasing left ventricular end-diastolic diameter and N-terminal pro–B-type natriuretic peptide.ConclusionsOur results demonstrate adipose tissue depot–specific alterations of synthesis of FA and inflammatory and metabolic mediators in systolic HF patients. EAT may be a source of increased circulatory and myocardial levels of these mediators through endocrine actions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cardiac Failure - Volume 21, Issue 11, November 2015, Pages 916–923
نویسندگان
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