کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2965611 1578160 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The role of RhoA/Rho kinase pathway in endothelial dysfunction
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
The role of RhoA/Rho kinase pathway in endothelial dysfunction
چکیده انگلیسی
Endothelial dysfunction is a key event in the development of vascular disease, and it precedes clinically obvious vascular pathology. Abnormal activation of the RhoA/Rho kinase (ROCK) pathway has been found to elevate vascular tone through unbalancing the production of vasodilating and vasoconstricting substances. Inhibition of the RhoA/ROCK pathway can prevent endothelial dysfunction in a variety of pathological conditions. This review, based on recent molecular, cellular, and animal studies, focuses on the current understanding of the ROCK pathway and its roles in endothelial dysfunction.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cardiovascular Disease Research - Volume 1, Issue 4, October–December 2010, Pages 165-170
نویسندگان
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