کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2966785 | 1178816 | 2012 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Genotype–phenotype correlation related to lipid profile in beta-thalassemia major and intermedia in southern Iran Genotype–phenotype correlation related to lipid profile in beta-thalassemia major and intermedia in southern Iran](/preview/png/2966785.png)
BackgroundBeta-thalassemia is commonly associated with lipid abnormalities. The aim of this study was to search for links between these lipid alterations and different types of β-thalassemia mutations.MethodsThe study, conducted from 2009 to 2010, included 100 patients with thalassemia major (TM) and 100 with thalassemia intermedia (TI). The control group was selected from 100 age- and sex-matched healthy individuals with normal hematologic indices. Serum lipid profiles, including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG), were determined and their relationship with different covariates, including different β-globin gene mutations, was analyzed.ResultsPatients with TI had significantly lower values for TC, LDL-C, HDL-C, and LDL-C/HDL-C ratio compared with TM patients and controls (P < .001). TG was greater in TM compared with TI patients (P = .001) and healthy individuals (P = .007). Hemoglobin was positively associated with TC (P < .001), LDL-C (P = .004), and HDL-C (P = .01) in TM patients. Splenectomy correlated with greater TC (P = .006) and LDL-C (P = .01) in TI patients, but only with greater LDL-C in TM patients (P = .02). The average amounts of TC and LDL-C were lower in persons with the β0/β0 mutation compared with the β+/β+ group.ConclusionLower amounts of TG, TC, LDL-C, and HDL-C were seen in TI patients compared with TM patients and healthy individuals. The severity of the genotype (ie, β0 type mutations compared with β+ type mutations) affected the degree of reduction in serum lipids.
Journal: Journal of Clinical Lipidology - Volume 6, Issue 2, March–April 2012, Pages 108–113