کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2998987 | 1180267 | 2010 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Glycemic Control and Weight Reduction Without Causing Hypoglycemia: The Case for Continued Safe Aggressive Care of Patients With Type 2 Diabetes Mellitus and Avoidance of Therapeutic Inertia
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کلمات کلیدی
LDL-CVADTEASDGLP-1IFGHDL-CNHANESCHDACCORDIGTLiraglutide Effect and Action in DiabetesFPGHbA1cDPP-4PPGMyocardial infarction - آنفارکتوس میوکاردimpaired glucose tolerance - اختلال تحمل گلوکزImpaired fasting glucose - اختلال قندخون ناشتاAction to Control Cardiovascular Risk in Diabetes - اقدام برای کنترل خطر قلبی عروقی در دیابتEuropean Association for the Study of Diabetes - انجمن اروپایی برای مطالعه دیابتAmerican Diabetes Association - انجمن دیابت آمریکاNational Health and Nutrition Examination Survey - بررسی بهداشت و تغذیه ملیcoronary heart disease - بیماری عروق کرونر قلبcardiovascular disease - بیماری قلب و عروقیCooperative Health Research in the Region of Augsburg - تحقیقات بهداشت همگانی در منطقه آگسبورگDiabetes mellitus - دیابت قندیdipeptidyl peptidase 4 - دیپپتیدیل پپتیداز 4CVD - رسوب دهی شیمیایی بخار Lead - سربbody mass index - شاخص توده بدنBMI - شاخص توده بدنیBlood pressure - فشارخونFasting plasma glucose - قند خون ناشتاhigh-density lipoprotein cholesterol - لیپوپروتئین پرچگالی یا اچدیالMONICA - مونیکاHemoglobin A1c - هموگلوبین A1cADA - وجود داردglucagon-like peptide 1 - پپتید مشابه گلوکاگون 1ADVANCE - پیشرفتProactive - پیشگیرانهtotal cholesterol - کلسترول تامLow-density lipoprotein cholesterol - کلسترول لیپوپروتئین با چگالی کمKORA - کوراPostprandial glucose - گلوکز پس از فروپاشی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
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چکیده انگلیسی
Diabetes mellitus (DM) is a major and growing concern in the United States, in large part because of an epidemic of obesity in America and its relation to type 2 DM. In affected patients, postprandial glucose may be an early indicator of glucose intolerance or a prediabetes condition, which may be a better predictor of cardiovascular risk than impaired fasting glucose level. Treating patients who have early signs of hyperglycemia, including elevated postprandial glucose level, with intensive glucose control that does not lead to weight gain, and ideally may be associated with weight reduction, may be vital to preventing or reducing later cardiovascular morbidity and mortality. Because hypoglycemia is an important complication of current DM treatments and may cause acute secondary adverse cardiovascular outcomes, not causing hypoglycemia is mandatory. Given that weight loss can significantly lower cardiovascular risk and improve other cardiovascular risk factors in patients with type 2 DM and that medications are available that can result in weight reduction without leading to hypoglycemia, the successful treatment of patients with type 2 DM should be individualized and should address the complete pathophysiologic process. This review is a hypothesis article that presents arguments against general approaches to the treatment of type 2 DM. An algorithm is presented in which the goal for managing patients with type 2 DM is to lower the blood glucose level as much as possible for as long as possible without causing hypoglycemia. In addition, body weight should ideally be improved, reducing cardiovascular risk factors and avoiding therapeutic inertia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mayo Clinic Proceedings - Volume 85, Issue 12, Supplement, December 2010, Pages S15-S26
Journal: Mayo Clinic Proceedings - Volume 85, Issue 12, Supplement, December 2010, Pages S15-S26
نویسندگان
Stanley S. MD, Benjamin A. MD,