کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3001911 1180685 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
High-density lipoprotein oxidation in type 2 diabetic patients and young patients with premature myocardial infarction
ترجمه فارسی عنوان
اکسیداسیون لیپوپروتئین با چگالی بالا در بیماران دیابتی نوع 2 و افراد جوان مبتلا به انفارکتوس میوکارد پیش از موعد
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی


• Oxidative damage can generate dysfunctional HDL reducing its anti-atherogenic role.
• Increased MetO levels in ApoA-I in patients with premature MI and in type 2 DM.
• An increase in MetO levels in ApoA-I could result in HDL dysfunction.

Background and aimsApoA-I can undergo oxidative changes that reduce anti-atherogenic role of HDL. The aim of this study was to seek any significant differences in methionine sulfoxide (MetO) content in the ApoA-I of HDL isolated from young patients with coronary heart disease (CHD), type 2 diabetics and healthy subjects.Methods and resultsWe evaluated the lipid profile of 21 type 2 diabetic patients, 23 young patients with premature MI and 21 healthy volunteers; we determined in all patients the MetO content of ApoA-I in by MALDI/TOF/TOF technique. The typical MALDI spectra of the tryptic digest obtained from HDL plasma fractions all patients showed a relative abundance of peptides containing Met112O in ApoA-I in type 2 diabetic and CHD patients. This relative abundance is given as percentages of oxidized ApoA-I (OxApoA-I). OxApoA-I showed no significant correlations with lipoproteins in all patients studied, while a strong correlation emerged between the duration of diabetic disease and OxApoA-I levels in type 2 diabetic patients.ConclusionsThe most remarkable finding of our study lies in the evidence it produced of an increased HDL oxidation in patients highly susceptible to CHD. Levels of MetO residues in plasma ApoA-I, measured using an accurate, specific method, should be investigated and considered in prospective future studies to assess their role in CHD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition, Metabolism and Cardiovascular Diseases - Volume 25, Issue 4, April 2015, Pages 418–425
نویسندگان
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