کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3002600 | 1180736 | 2012 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Retention of atherogenic lipoproteins in the artery wall and its role in atherogenesis Retention of atherogenic lipoproteins in the artery wall and its role in atherogenesis](/preview/png/3002600.png)
AimsIn this review, we discuss the mechanisms behind the binding of low-density lipoproteins (LDL) to the arterial wall and how this interaction might be targeted to prevent atherosclerosis.Data synthesisAn increasing body of evidence shows that accumulation of LDL in the vessel wall is a critical step in the development of atherosclerosis. The retained lipoproteins subsequently provoke an inflammatory response that ultimately leads to atherosclerosis. In the arterial wall, LDL binds ionically to proteoglycans in the extracellular matrix. In particular, proteoglycans with elongated glycosaminoglycan (GAG) chains seem to play a crucial role in this process.ConclusionsThe LDL-proteoglycan interaction is a highly regulated process that might provide new therapeutic targets against cardiovascular disease.
Journal: Nutrition, Metabolism and Cardiovascular Diseases - Volume 22, Issue 1, January 2012, Pages 1–7