کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3026775 | 1182918 | 2015 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Pedunculopontine arousal system physiology—Effects of psychostimulant abuse Pedunculopontine arousal system physiology—Effects of psychostimulant abuse](/preview/png/3026775.png)
This review describes the interactions between the pedunculopontine nucleus (PPN), the ventral tegmental area (VTA), and the thalamocortical system. Experiments using modulators of cholinergic receptors in the PPN clarified its role on psychostimulant-induced locomotion. PPN activation was found to be involved in the animal’s voluntary search for psychostimulants. Every PPN neuron is known to generate gamma band oscillations. Voltage-gated calcium channels are key elements in the generation and maintenance of gamma band activity of PPN neurons. Calcium channels are also key elements mediating psychostimulant-induced alterations in the thalamic targets of PPN output. Thus, the PPN is a key substrate for maintaining arousal and REM sleep, but also in modulating psychostimulant self-administration.
Journal: Sleep Science - Volume 8, Issue 3, November 2015, Pages 162–168