کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3035099 1579556 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cardiac autonomic function does not improve after liver transplantation for familial amyloidotic polyneuropathy
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Cardiac autonomic function does not improve after liver transplantation for familial amyloidotic polyneuropathy
چکیده انگلیسی

ObjectiveLiver transplantation is the only potentially curative treatment for familial amyloidotic polyneuropathy (FAP). We investigated cardiac autonomic function in 63 transplanted Swedish FAP patients.MethodsHeart rate variability (HRV) was recorded between 1–17 (mean 8) months before, and 10–40 (mean 20) months after transplantation. HRV was analysed by power spectrum analysis, but only in patients without arrhythmia (n = 38).ResultsPatients with moderate cardiac autonomic dysfunction showed a statistically significant reduction in HRV after transplantation, as compared to the pre-transplant recording. Patients with severe cardiac autonomic dysfunction presented unchanged HRV after liver transplantation. Twenty patients were excluded because they presented cardiac arrhythmia, five of these presented increased HRV after transplantation but had developed subtle arrhythmias, thus, they had not improved cardiac autonomic control. Five patients were excluded because they were pacemaker-treated.ConclusionsThe reason why HRV decreased after transplantation remains unclear, but there are several possibilities: 1) liver transplantation did not stop the deterioration in cardiac autonomic function; 2) the deterioration continued until transplantation and was then halted; or 3) a sudden reduction in HRV occurred in connection with the transplantation procedure. Nonetheless, this study failed to disclose any improvement in cardiac autonomic function after liver transplantation for FAP.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Autonomic Neuroscience - Volume 156, Issues 1–2, 25 August 2010, Pages 124–130
نویسندگان
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