کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3035836 | 1579583 | 2006 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Optical recording of vagal pathway formation in the embryonic brainstem
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کلمات کلیدی
NMDAN-methyl-d-aspartatePBNAPVdl-2-amino-5-phosphonovaleric acidNTSDMNV6-cyano-7-nitroquinoxaline-2, 3-dione - 6-سینو-7-نیتروکینکسالین-2، 3-دیونDiI - DIIEPSP - epspiγ-aminobutyric acid - اسید γ-آمینوبوتیریکEmbryo - جنینvoltage-sensitive dye - رنگ حساس به ولتاژembryonic day - روز جنینیCNQX - سیانکیوایکسoptical recording - ضبط نوریvagus nerve - عصب واگparabrachial nucleus - هسته parabrachialNucleus of the tractus solitarius - هسته از دستگاه انفرادیDorsal motor nucleus of the vagus nerve - هسته موتور پشتی عصب واگSynapse - همایه یا سیناپسexcitatory postsynaptic potential - پتانسیل پست سیناپتی هیجان انگیزGABA - گابا
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Optical recording of vagal pathway formation in the embryonic brainstem Optical recording of vagal pathway formation in the embryonic brainstem](/preview/png/3035836.png)
چکیده انگلیسی
Multiple-site optical recording with a fast voltage-sensitive dye, absorption dye NK2761, was used to study the developmental organization of functional synaptic networks in the vagal pathway. Glutamatergic excitatory postsynaptic potentials (EPSPs) evoked by vagus nerve stimulation was first detected from the nucleus of the tractus solitarius (NTS) at embryonic day 7 (E7) in chick embryos and E15 in rat embryos, when morphological differentiation of pre- and postsynaptic neurons is incomplete. When extracellular Mg2+ was removed, small EPSPs were elicited at E6 in chick embryos and E14 in rat embryos. These results suggest that synaptic function mediated by N-methyl-d-aspartate (NMDA) receptors is latently generated 1 day before the expression of glutamatergic EPSP. Functional synapses related to the glossophyaryngeal nerve appear to be generated at the same time as the vagus nerve, but their spatial distribution was different from that of the vagus nerve. We further investigated the development of second synaptic pathways from the NTS to higher centers, and found that neuronal circuits from the NTS are already generated when the primary afferents form functional synapses with NTS neurons.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Autonomic Neuroscience - Volumes 126â127, 30 June 2006, Pages 39-49
Journal: Autonomic Neuroscience - Volumes 126â127, 30 June 2006, Pages 39-49
نویسندگان
Yoko Momose-Sato, Katsushige Sato,