کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3036131 1184357 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Firing dynamics and LFP oscillatory patterns in the dopamine-depleted striatum during maze learning
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Firing dynamics and LFP oscillatory patterns in the dopamine-depleted striatum during maze learning
چکیده انگلیسی
Dopamine loss in Parkinson's disease (PD) is most severe initially in the dorsolateral part of the striatum (DLS) and spread over time to other striatal regions. The DLS is thought to play a critical role for the acquisition of habitual motor behaviors and procedural tasks. During such habit-like, procedural learning, a subset of medium spiny neurons (MSNs) in the DLS develops pronounced activity around the beginning and the end of a T-maze task. Dopaminergic input to the DLS may be required for habit formation in instrumental conditioning tasks, such as the T-maze task. Here I review data characterizing the effects of focal dopamine depletion, mimicking early stages of PD, and l-DOPA therapy on the firing activity of different subpopulations of striatal neurons and on oscillatory patterns in local field potential (LFP) activity during the learning and performance of a conditional maze task.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Basal Ganglia - Volume 3, Issue 4, April 2014, Pages 213-219
نویسندگان
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