کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3039460 1579673 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cognitive performance, fatigue and event-related potentials in patients with clinically isolated syndrome
ترجمه فارسی عنوان
عملکرد شناختی، خستگی و پتانسیل مربوط به رویداد در بیماران مبتلا به سندرم انحصاری بالینی
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی


• 45% of patients with clinically isolated syndrome (CIS) showed impaired cognitive performance.
• Parameters of event-related potentials differed between patients with CIS and controls.
• 18% of patients with CIS reported moderate or severe fatigue.
• Cognition and fatigue deserve attention from the earliest stage of multiple sclerosis.

ObjectivesCognitive impairment and fatigue are regarded as important aspects of multiple sclerosis. The aim of this study was to evaluate cognitive performance, the level of fatigue and parameters of event-related potentials (ERP) in patients diagnosed with clinically isolated syndrome (CIS).Patients and methodsThe study comprised 44 patients with CIS and 45 healthy controls. Cognitive performance was assessed using the Brief Repeatable Battery of Neuropsychological Tests (BRBNT), fatigue - using the Fatigue Severity Scale (FSS) and Modified Fatigue Impact Scale (MFIS). Auditory ERP were performed and the parameters of N200 and P300 components were analyzed. Neuropsychological and electrophysiological measures were referred to clinical and radiological features of the disease activity.ResultsForty five% of patients failed in at least one test from BRBNT, mainly within the domains of memory and attention. In 18% of patients FSS corresponded with moderate or severe fatigue. The mean latency of N200 and P300 was significantly longer and amplitude of P300 was lower in those patients with CIS than in the controls. Significant correlations were found between the results of MFIS and tests evaluating verbal memory and attention, as well as between N200 latency and results of tests for verbal memory.ConclusionsCognitive performance and fatigue deserve attention from the earliest clinical stage of MS. Abnormalities of event-related potentials in CIS suggest early impact of the disease on functional neural networks.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Neurology and Neurosurgery - Volume 149, October 2016, Pages 68–74
نویسندگان
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