A case of pediatric atypical prolactinoma: significance of a multidisciplinary treatment approach

• There are a small subset of atypical prolactinoma showing a rapid tumor growth and a high rate of recurrence in PRL-producing pituitary adenomas.
• This non-benign phenotype shows high mitotic acitivity, high Ki-67 proliferative index >3% and positive immunoreactivity for p53.
• Progressive intolerable headache and severe visual disturbance with rapid tumor growth should be kept in our minds as important clinical manifestations of atypical adenoma.
• When an atypical phenotype of prolactinoma is suspected, histological verification of surgical specimens is essential before medical therapy with a dopamine agonist.