The squares test as a measure of hand function in multiple sclerosis

• We examine the validity of the squares test as a measure of hand function in MS.
• The test is compared to the 9-hole peg test, a standard in the MSFC.
• The ST shows high correlation with the 9HPT and comparable discriminatory power.
• The ST is a good candidate for use in composite measures of functional deficits

Deterioration of hand function can be important in multiple sclerosis (MS). The standard way of assessing hand function in MS is the 9-hole peg test (9HPT), one of the three components of the MS functional composite measure. In this study we examine the squares test (ST), a test of hand function that is used extensively in handedness research.We evaluated reproducibility of the ST in 49 healthy controls, and both discriminatory power and concurrent validity of the ST in 38 MS patients and 18 age and gender matched controls.The ST proved to be a reliable and easy to administrate paper-and-pencil test of hand function. The ST showed a high and highly significant correlation with the standard 9HPT over a broad range of Expanded Disability Status Scale (EDSS) scores, and had high discriminatory power, also comparable to the 9HPT.Therefore, the ST is a candidate test for use in composite measures of MS related functional deficits for clinical practice and in clinical trials.