کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3040251 1579700 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Occlusion of canine aneurysms using microporous self-expanding stent grafts: Long-term follow-up
ترجمه فارسی عنوان
تداخل آنوریسم های کانین با استفاده از گرافت های استنت گریز از خودکفایی کوچک: پیگیری طولانی مدت
کلمات کلیدی
گشتاور سنتز خودکارشناسی میکروپروسسوری، آنوریسم تجربی سگ، پیوند های ستون هیبرید، استنت تحت پوشش، پیگیری طولانی مدت
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی


• We developed microporous self-expanding stent grafts for cerebral aneurysm occlusion.
• At 1 year of occlusion, all parent arteries were patent without significant stenosis.
• All aneurysms with hybrid grafts remained occluded, 33% with bare stent grafts.
• Histology revealed hybrid stent grafts had less intimal hyperplasia.
• The hybrid stent grafts are expected to overcome the demerits of fully covered stents.

PurposeThe treatment of large or giant cerebral aneurysms by surgical and/or endovascular techniques is difficult and poses relatively high risks. Therefore, a microporous self-expanding (hybrid) stent graft composed of a thin, expandable, segmented polyurethane (SPU) membrane with micropores and a drug-delivery system was developed.Materials and methodsA commercially available, self-expanding carotid stent was covered with a thin microporous SPU membrane fabricated by the dip-coating method and the excimer laser ablation technique, with an intraluminal coating of argatroban. Experimentally fabricated lateral-wall aneurysms in canine carotid arteries using venous pouches were occluded with the hybrid stent graft (bale-shaped pore density of 23.6%) on one side and a bare-metal stent on the other side without systemic antiplatelet therapy.ResultsAngiography at 1, 6, and 12 months of stenting revealed that all arteries were patent without marked stenosis without systemic antiplatelet therapy. All aneurysms treated with hybrid stent grafts remained occluded throughout the 12-month period, while among those treated by bare-metal stents, 2 of 3 aneurysms were occluded at 6 months (67%) and only 1 of 3 aneurysms were occluded at 12 months (33%). Histology revealed that the novel hybrid stent graft had less intimal hyperplasia than the bare-metal stent. The hybrid stent graft was useful for the successful occlusion of these canine carotid aneurysms, even at 12 months.ConclusionsThe novel hybrid stent grafts are expected to overcome the disadvantages of fully covered stent grafts and simple bare-metal stents, while combining both their merits, and appear to be useful in the treatment of large or giant cerebral aneurysms.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Neurology and Neurosurgery - Volume 122, July 2014, Pages 34–41
نویسندگان
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