Delayed leukoencephalopathy after alprazolam and methadone overdose: A case report and review of the literature

► A case of delayed leukoencephalopathy after mixed overdose is described.
► MR images and spectroscopy are characteristic of demyelinating lesions.
► DLE is characterised by similar findings regardless of the initial insult.
► The role of errors of myelin metabolism e.g. arylsulfatase A remains unconfirmed.