کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3040981 1184757 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Increased total homocysteine level is associated with clinical status and severity of white matter changes in symptomatic patients with subcortical small vessel disease
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Increased total homocysteine level is associated with clinical status and severity of white matter changes in symptomatic patients with subcortical small vessel disease
چکیده انگلیسی

ObjectiveElevated plasma total homocysteine (tHcy) is an independent risk factor for ischemic stroke and has been linked to cerebral small vessel disease (SVD), in particular. Controversy persists as to whether increased tHcy is associated with functional status and cognitive decline in these patients.MethodsPlasma tHcy, MTHFR polymorphism, vascular risk factors, functional and cognitive status and severity of lesions on MRI, assessed with the Age-Related White Matter Changes (ARWMC) visual grading scale, were analyzed in 95 patients with SVD and 41 healthy control subjects.ResultsPlasma tHcy levels were higher in patients with SVD (14.4 ± 5.0 μmol/L) compared to healthy SVD-free controls (8.9 ± 3.9 μmol/L). In SVD patients, tHcy levels strongly correlated with cognitive status (age-adjusted risk 5.8, 95% CI 1.3–25.3, p = 0.015), functional status (age-adjusted risk 3.2, 95% CI 1.2–8.8, p = 0.022) and severity of MRI lesions (age-adjusted risk 1.2, 95% CI 1.1–1.4; p = 0.004). Only total ARWMC score was independently associated with increased tHcy levels (OR 1.2, 95%CI 1.1–1.4, p = 0.004). Independent predictors of WMC occurrence were tHcy levels (OR 1.2, 95%CI 1.1–1.3, p = 0.003) and mRS score (OR 2.2, 95%CI 1.2–4.1, p = 0.017).ConclusionsIn patients with cerebral SVD there is a positive association of increased plasma tHcy levels with clinical status and severity of WMC.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Neurology and Neurosurgery - Volume 113, Issue 9, November 2011, Pages 711–715
نویسندگان
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