کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3041113 1184761 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Kinesin family member 2C (KIF2C/MCAK) is a novel marker for prognosis in human gliomas
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Kinesin family member 2C (KIF2C/MCAK) is a novel marker for prognosis in human gliomas
چکیده انگلیسی

ObjectiveGliomas are a group of center nervous system tumors of glial origin. Most are characterized by diffuse infiltrative growth in the surrounding brain. Patients almost always ultimately die from their disease. The drastically increased knowledge about the molecular abnormalities, these are linked with tumor grade and patient prognosis. The aim of this study was to examine the role of KIF2C and AURKB as prognostic factors in gliomas.Materials and methodsA total 40 tumor samples and 6 normal brain tissue samples were collected. Biomarker KIF2C and AURKB were tested by qRT-PCR. Using Western blot validate the results.ResultsWe found that KIF2C and AURKB genes were higher expression in glioma samples when were compared with normal brain tissues. KIF2C and AURKB expression were associated with histopathological grades. We found that KIF2C as a potential independent prognostic marker for patient with glioma by Cox analysis.ConclusionThe expression level of KIF2C mRNA could be a potential independent marker to evaluate patient prognosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Neurology and Neurosurgery - Volume 114, Issue 4, May 2012, Pages 356–360
نویسندگان
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