کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3041116 1184761 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Correlational study of the serum levels of the glial fibrillary acidic protein and neurofilament proteins in Parkinson's disease patients
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Correlational study of the serum levels of the glial fibrillary acidic protein and neurofilament proteins in Parkinson's disease patients
چکیده انگلیسی

ObjectiveTo investigate changes in the serum levels of the glial fibrillary acidic protein (GFAP) and neurofilament proteins (NFs) in patients with Parkinson's disease (PD) and to determine their clinical significance.MethodsIn this study, 82 subjects were divided into 3 groups: the PD group, the acute cerebral infarction (ACI) group, and a normal control group. The serum levels of GFAP and NFs were measured using a sandwich ELISA assay.ResultsThe serum levels of GFAP and NFs were significantly higher in the PD and the ACI groups than in the normal control group (P < 0.05). There was no significant difference between the PD group and the ACI group (P > 0.05). The serum level of GFAP in the PD group had no significant correlation with duration of the disease or age (P > 0.05). The serum level of NFs in the PD group was significantly correlated with duration of the disease and age (P < 0.05).ConclusionsThe serum levels of GFAP and NFs were significantly higher in the PD group than in the normal group, indicating that astrocytic activity may remain elevated during the axonal degeneration that occurs over duration of the disease, although this activity is not specific to the disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Neurology and Neurosurgery - Volume 114, Issue 4, May 2012, Pages 372–375
نویسندگان
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