کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3041468 1184777 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Glioblastoma multiforme in the Muir–Torre syndrome
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Glioblastoma multiforme in the Muir–Torre syndrome
چکیده انگلیسی

Muir–Torre syndrome (MTS) is an autosomal dominant subtype of nonpolyposis colorectal carcinoma (HNPCC) characterized by the development of sebaceous gland tumors and visceral malignancies. The most common subtype of MTS is characterized by germline mutations in mismatch repair (MMR) genes leading to microsatellite instability (MSI). Central nervous system tumors have only rarely been associated with MTS. In this report, we describe the development of a glioblastoma multiforme (GBM) in a patient with MTS. Immunohistochemical analysis of the patient's colon carcinoma and his GBM both revealed loss of the mismatch repair proteins mutS homolog 2 (MSH2) and mutS homolog 6 (MSH6).

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Neurology and Neurosurgery - Volume 113, Issue 5, June 2011, Pages 411–415
نویسندگان
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