Use of modafinil in patients with epilepsy

Fatigue and excessive daytime sleepiness are common symptoms in patients with neurological injury. Modafinil has been shown to ameliorate these symptoms, but its use in patients with seizures has been limited because of safety concerns. Using a large centralized clinical registry, we performed a retrospective chart review of patients with a diagnosis of epilepsy who were given modafinil over a 10-year period. A total of 205 patients were analyzed. There were 91 patients who had seizures while taking modafinil; there was no relationship between modafinil dosage and whether the patient had seizures. There were 6 patients in whom modafinil was discontinued because of concern for seizure exacerbation, and 4 patients had de novo seizures after starting modafinil. In 29 patients with epilepsy only, no major seizure exacerbation was seen. Modafinil is potentially safe in patients with epilepsy, but further prospective studies are needed to fully determine its safety and efficacy.

► Modafinil use in patients with seizures is limited due to safety concerns.
► We identified 205 patients with diagnosis of epilepsy who were given modafinil.
► Six patients were discontinued because of concerns for seizure exacerbation.
► There is no dose effect of modafinil on whether patients experienced seizures.
► Modafinil does not appear to exacerbate seizures.