کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3050043 1185943 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Long-term vagus nerve stimulation in the treatment of Lennox–Gastaut syndrome
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Long-term vagus nerve stimulation in the treatment of Lennox–Gastaut syndrome
چکیده انگلیسی

The long-term effects of vagus nerve stimulation (VNS) on seizure frequency were studied in 30 patients with Lennox–Gastaut syndrome. Median observation time was 52 months (17–123). The effect parameters investigated were total number of seizures and different seizure types. The median reduction in number of seizures was 60.6%. The effects of VNS varied considerably between seizure types. Best effects were observed with atonic seizures (80.8% median reduction, number of responders: 8/12), followed closely by tonic seizures (73.3% median reduction, number of responders: 8/13). Least effects were with generalized tonic–clonic seizures (median reduction 57.4%, number of responders: 11/20). Additional positive effects included milder or shorter ictal or postictal phase in 16 patients. Improved alertness was reported in 76.7%. Adverse effects, of which drooling and voice alteration were most frequent, were reported in 20 patients. There was a statistically significant reduction in the median number of antiepileptic drugs used. The discontinuation rate was 16.7%.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy & Behavior - Volume 16, Issue 2, October 2009, Pages 321–324
نویسندگان
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